LONG-TERM RESULTS OF PHARMACOLOGICAL CORRECTION OF INOS, ENOS, NNOS MRNA EXPRESSION DISORDERS IN RAT HIPPOCAMPUS AFTER CHRONIC PRENATAL HYPOXIA


  • I.F. Belenichev Department Department of Pharmacology and Medical Formulation, Zaporizhzhia State Medical University, Ukraine
  • O.G. Aliyeva Department of Histology, Cytology and Embryology, Zaporizhzhia State Medical University, Ukraine
  • А. M. Kamyshnyi Department of Microbiology, Virology and Immunology, Zaporizhzhia State Medical University, Ukraine
Keywords: chronic prenatal hypoxia (CPH), NO synthase (NOS), Angiolin.

Abstract

LONG-TERM RESULTS OF PHARMACOLOGICAL CORRECTION OF INOS, ENOS, NNOS MRNA EXPRESSION DISORDERS IN RAT HIPPOCAMPUS AFTER CHRONIC PRENATAL HYPOXIA

References

1. Urazov M. D., Astrakhanova Т. А., Usenko А. V. et al. New aspects of central nervous system adaptation to prenatal hypoxia // Sovremennye tehnologii v medicine. 2018; 10(4): 60-68.

2. Sukhanova I. A., Sebentsova E. A., Levitskaya N. G. The Acute and Delayed Effects of Perinatal Hypoxic Brain Damage in Children and in Model Experiments with Rodents // Neurochemistry. 2016; 33(4): 276–292.

3. Sozaeva D. I., Berezhanskaya S. B. Pathogenetic mechanisms of brain damage in infants undergoing hypoxia in the perinatal period // Modern problems of science and education. 2014; 4: URL: http://www.science-education.ru/ru/ article/view?id=14340.

4. Millar L. J., Shi L., Hoerder-Suabedissen A. et al. Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges // Front Cell Neurosci. 2017; 11:78.

5. Belenichev I. F., Aliyeva E. G. New targets for pharmacological correction of cognitive disorders in prenatal hypoxia action //Pharmacology and Drug Toxicology. 2019; 13 (4): 235-248.

6. Bal N. V., Rysakova M. P., Vinarskaya A. Kh. at al. Cued memory reconsolidation in rats requires nitric oxide // Euro- pean Journal of Neuroscience. 2017; 45 (5): 643-647.

7. Tomilova I. K., Slobodin V. B. Nitric oxide production indices in ontogenesis under antenatal hypoxia in rats // Bulletin of the Ivanovo Medical Academy. 2011; 16 (2): 25-29.

8. Malakhov V. A., Zavgorodnaya A. N., Lychko V. S. at al. The problem of nitric oxide in neurology. Monograph. 2009; 242. http://essuir.sumdu.edu.ua/handle/ 123456789/26286.

9. Lubos E., Handy D. E., Loscalzo J. Role of oxidative stress and nitric oxide in atherothrombosis //Front Biosci. 2008; 1(13): 5323-5344.

10. Belenichev I. F., Gorbacheva S. V., Demchenko A. V. at al. The Thiol-Disulfide Balance and the Nitric Oxide System in the Brain Tissue of Rats Subjected to Experimental Acute Impairment of Cerebral Blood Flow: The Therapeutic Effects of Nootropic Drugs //Neurochemical Journal, 2014; 8 (1): 24–27.

11. Baranov A. A., Namazova-Baranova L. S., Karkashadze G. A.. New neurobiological approaches to prevention and treatment of perinatal CNS lesions //Russian Academy of Sciences. 2017; 106.

12. Chu G. L., Xin Y., Cheng J. at al. Expression of neuronal nitric oxide synthase in brain tissue of hypoxic-ischemic neo- natal rat and the cerebral protective effect of neuronal nitric oxide synthase inhibitor 7-nitroindazole //Zhonghua Yi Xue Za Zhi. 2004; 84(2): 156-158.

13. Bastian Ch., Zaleski J., Stahon K. et al. NOS3 Inhibition Confers Post- Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels //J Neurosci. 2018; 38 (28): 6247-6266.

14. Novikov V. E., Levchenkova O. S., Pozhilova E. V. Mitochondrial nitric oxide synthase and its role in the mechanisms of cell adaptation to hypoxia // Reviews on clinical pharmacology and drug therapy. 2016; 14 (2): 38-44.

15. Yu L., Derrick M., Ji H. at al.·Neuronal Nitric Oxide Synthase Inhibition Prevents Cerebral Palsy following Hypoxia-Is- chemia in Fetal Rabbits: Comparison between JI-8 and 7-Nitroindazole //Dev Neurosci. 2011; 33: 312–319.

16. Bielenichev I. F., Stebliuk V. S., Kamyshnyi O. M. The mRNA expression character of iNOS and eNOS in the rats my- ocardium with alcoholic cardiomyopathy during metabolitotropic cardioprotectors therapy // Bulletin of problems biology and medicine. 2017; 136 (2): 82-85.

17. Egorov A. N., Belenichev I. F., Sokolik E. P. at al. The role of nitrosating stress in the mechanisms of neurodegradation under conditions of prenatal alcohol intoxication and ways of pharmacocorrection of occurring disorders //Zapor- ozhye medical journal. 2012; 5: 25-28.

18. Belenichev I. F., Pavlyuk I. V., Abramov A. V. at al. The influence of Angiolin on the morphological and functional param- eters of CA1 region of the hippocampus and on the neuroapoptosis processes in experimental chronic alcohol intox- ication under therapeutic mode of administration //Bulletin of problems biology and medicine. 2016; 126 (1): 130-134.

19. Belenichev I. F., Cherniy V. I., Nagorna E. A. At al. Neuroprotection and Neuroplasticity: Monograph //Kiev. 2015; 512.

20. Mazur I. A., Belenichev I. F., Kolesnik J. M. at al. Lysinium 3-methyl-1,2,4-triasolyl-5-thioacetate with neuroprotective, nootropic, cardioprotective, endotheliotropic, anti-ischemic, antioxidant, anti-inflammatory and antihypoxic effect and low toxicity// Patent RU 2370492 C2 Russian federation, Int. Cl. C07D 249/12 (2006.01) A61K 31/41 (2006.01).

21. Nyakas C., B. Buwalda, Luiten P.G. Hypoxia and brain development //Prog. Neurobiol. 1996. 49: 1-51.

22. Cherkesova. D. U., Magomedgadzhieva D. N., Rabadanova A. I. Functional changes in system mother-fetus at exper- imental chronic nitrite hypoxia //Izvestia of RAS SamSC. 2016; 11 (5): 934-937.

23. Sosedova L. M., Vokina V. A., Rukavishnikov V. S. Method for simulating prenatal hypoxic encephalopathy in small laboratory animals // Patent RU 2497202 C1 Russian federation, Int. Cl. G09B 23/28 (2006.01)

24. Liu H., Li J., Zhao F. et al. Nitric oxide synthase in hypoxic or ischemic brain // Rev. Neurosci. 2015; 26(1): 105–117.

25. Viktorov I. V. The role of nitric oxide and other free radicals in ischemic brain pathology // Annals of the Russian acad- emy of medical sciences. 2000; 4: 5-10.

26. Bolaños J. P., Angeles A. Roles of nitric oxide in brain hypoxia-ischemia //Biochimica et Biophysica Acta. 1999; 1411 (2–3): 415-436.

27. Van den Tweel E. R., Peeters-Scholte C. M., Van Bel F. et al. Inhibition of nNOS and iNOS following hypoxia-ischaemia improves long-term outcome but does not influence the inflammatory response in the neonatal rat brain // Dev. Neurosci. 2002; 24(5): 389-95.

28. Van den Tweel, ER, Van Bel, F, Kavelaars [et al.]Neuroprotection with 2-iminobiotin, an inhibitor of neuronal and in- ducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats / // J Cereb Blood Flow Metab. – 2005. - V.25. – Р.67–74.

29. Dagdeviren М. Role of Nitric Oxide Synthase in Normal Brain Function and Pathophysiology of Neural Diseases// Chapter 3 in the book: Nitric Oxide Synthase - Simple Enzyme-Complex Roles. Edited by Saravi S. S. 2017: 37-54.

30. Haiting L., Jiao L., Fengyan Z. at al. Nitric oxide synthase in hypoxic or ischemic brain injury // Reviews in the neuro- sciences. 2015; 26(1): 105-117.

31. Lopez I., Acuna D., Beltran-Parrazal L.et al. Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air) //Neuroscience. 2009; 10(1): 53-71.

32. Ferreiro C. R., Palandri Chagas A. C., Catelli Carvalho M. H. at al. Influence of Hypoxia on Nitric Oxide Synthase Ac- tivity and Gene Expression in Children With Congenital Heart Disease// Circulation. 2001; 103: 2272–2276.

33. Xingping Q., Jing C., Zhong Y. et al. Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Is- chemic Encephalopathy //Front. Mol. Neurosci. 2019. 12: 88.

34. Wang H, Wang AX, Liu Z et al. The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates en- dothelial nitric oxide production // Mol Endocrinol. 2009: 23: 1613–1623.

35. Yagita Y, Kitagawa K, Oyama N. et al. Functional deterioration of endothelial nitric oxide synthase after focal cerebral ischemia // J Cereb Blood Flow Metab. 2013; 33(10): 1532–1539.

36. Belenichev I.F., Kucherenko L.I., Nagornaya E.A. at al. Functional nitric oxide conjugate systems state/restored heart thiols of rats in modeling isadrine-pituitrin’s myocardial infarction using metabolitetropic cardioprotector «Angiolin» // International Journal of Basic & Clinical Pharmacology. 2015; 4 (1): 15-21.

37. Chekman I.S., Kazakova O. A., Mazur I. A. at al. New original metabolitotropic endothelioprotector «Angiolin»: quan- tum-chemical parameters and peculiarities of pharmacological action // Dopov. Nac. acad. nauk Ukr. 2017; 8: 86-93.

38. Belenichev I. F., Mazur I. A., Kucherenko L. I. et al. Molecular and ultrastructural aspects of the formation of mitochon- drial dysfunction in modeling chronic cerebral ischemia: The mitoprotective effects of Angiolin // Neurochemistry. 2016; 2: 140-146.

39. Mazur I. A., Belenichev I. F, Pavlov S. V. at al. Energotropic mechanism of the cerebroprotective action of the new original medication “Lisiniy” in the model of the acute cerebral circulation insufficiency // Pharmacology and Toxi- cology. 2013; 4-5: 14-18.

40. Belenichev I.F., Bukhtiyarova N.V., Chekman I.S. at al. Influence of mexidol on early genomic response and morpho- functional parameters of the brain cortex sensorimotor zone neurons after arteria carotis communis occlusion // Oxid Antioxid Med Sci. 2015; 4 (1): 1-6

41. Belenichev I., Odnokoz O., Pavlov S. at al. The neuroprotective activity of tamoxifen and tibolone during glutathione depletion in vitro //Neurochemical Journal. 2012; 6 (3): 202-212.

42. Belenichev I. F., Voitenko D. S., Bukhtiayrova N. V. Reduce the Neuroapoptosis in the Brain of Rats Born to Mothers with Experimental Placental Insufficiency by Combination of Thiotriazoline with L-Arginine and Thiotriazolin with Piracetam // International Journal of Neurorehabilitation. 2019; 6 (2): 312-316.

43. Belenichev I. F., Bukhtiayrova N. V., Cherniy V.I. at al. Rational neuroprotection. Monograph. 2008: 264.
Published
2019-12-20
How to Cite
Belenichev, I., Aliyeva, O., & KamyshnyiА. M. (2019). LONG-TERM RESULTS OF PHARMACOLOGICAL CORRECTION OF INOS, ENOS, NNOS MRNA EXPRESSION DISORDERS IN RAT HIPPOCAMPUS AFTER CHRONIC PRENATAL HYPOXIA. Biological Markers in Fundamental and Clinical Medicine (scientific Journal), 3(2), 6-15. https://doi.org/10.29256/v.03.02.2019.escbm02