PREDICTION OF miRNA BINDING SITES IN GENES INVOLVED IN ALZHEIMER’S DISEASE


  • O.Yu. Yurikova Research Institute of Problems of Biology and Biotechnology, al-Farabi Kazakh National University, Kazakhstan
  • A. Bolshoy Department of Evolutionary and Environmental Biology, University of Haifa, Israel
Keywords: Alzheimer’s disease, miRNA, cluster of binding sites, target genes

Abstract

PREDICTION OF miRNA BINDING SITES IN GENES INVOLVED IN ALZHEIMER’S DISEASE

References

1. Lytle J.R, Yario T.A, Steitz, J.A. Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR. Proc. Natl Acad. Sci. 2007; 104:9667–9672.

2. Tay Y, Zhang J, Thomson A.M, Lim B, Rigoutsos I. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature. 2008; 455:1124–1128.

3. Kruger J, Rehmsmeier M. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res. 2006; 34:451–454.

4. Betel D, Koppal A, Agius P, Sander C, Leslie C. Comprehensive modeling of microRNA targets predicts functional non- conserved and non-canonical sites. Genome Biology. 2010; 11:R90

5. Femminella G.D, Ferrara N, Rengo G. The emerging role of microRNAs in Alzheimer’s disease. Front Physiol. 2015; 6:40

6. Danborg P.B, Simonsen A.H, Waldemar G, Heegaard N.H. The potential of microRNAs as biofluid markers of neurodegenerative diseases — a systematic review. Biomarkers. 2014; 19:259-268

7. Denk J, Boelmans K, Siegismund C, Lassner D, Arlt S, Jahn H. MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer’s disease. PLoS One. 2015; 10:e0126423

8. Ivashchenko A, Berillo O, Pyrkova A, Niyazova R, Atambayeva Sh. MiR-3960 binding sites with mRNA of human genes. Bioinformation. 2014; 10(7):423-427.

9. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, et al. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015;112(10):E1106–1115
Published
2018-11-15
How to Cite
Yurikova, O., & Bolshoy, A. (2018). PREDICTION OF miRNA BINDING SITES IN GENES INVOLVED IN ALZHEIMER’S DISEASE. Biological Markers in Fundamental and Clinical Medicine (scientific Journal), 2(2), 38-39. https://doi.org/10.29256/v.02.02.2018.escbm29
Section
Selected abstracts